Postoperative ileus is one of the most important and common complications after abdominal\nsurgery. This single-blind randomized clinical trial study was conducted with the aim of evaluating\nthe effect of oral pyridostigmine (60 mg) on the duration and frequency of response to the treatment\nof ileus after abdominal surgery on 40 patients in two 20-subject groups of oral pyridostigmine\n(interventional) and starch (control) in 2015. All 40 people completed the study process and entered\nthe final analysis. In the oral Pyridostigmin group (60 mg) the mean response time for the disposal of\ngas and stool were 5.4 �± 4.7 h and 4.9 �± 3.4 h, respectively. Most of the participants 10 (50%) (Disposal\nof stool) responded to treatment 4 h after the administration of oral pyridostigmine. In the starch\ngroup, the mean response time for the disposal of gas and stool were 32.4 �± 9.9 h and 36.2 �± 10.3 h,\nrespectively. The mean treatment response time in two groups showed a significant difference\nbetween both groups (p = 0.001). Regarding the frequency of response to treatment (disposal of gas\nor stool) in the 24-h period after the initiation of treatment in the oral pyridostigmine group, 95%\n(n = 19) of the subjects responded to the treatment in the first 24 h. However, in the starch group,\nonly 50% (n = 10) responded to treatment in the first 24 h, the results showed a significant difference\nbetween the two groups (p = 0.001). The results indicate that oral pyridostigmine can be used as a\nsimple and effective treatment for gastrointestinal ileus.
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